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Search Result

Search Results for " jak1 inhibitor "

20

Compounds

Cat No. Product Name Synonyms Targets
T77504 JAK1/2/3 Inhibitor 1 PKA
JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell lines. It inhibits the growth of cancer cells by binding to the c...
T39113L Povorcitinib phosphate JAK
Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.
T9195 SHR0302 ARQ252 Apoptosis , JAK
SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2).
T12266 Ilginatinib NS-018 Tyrosine Kinases , JAK
Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.
T7503 Upadacitinib ABT-494 JAK
Upadacitinib (ABT-494) (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor, which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM.
T12266L Ilginatinib maleate NS-018 maleate Tyrosine Kinases , JAK
Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.
T12266L2 Ilginatinib hydrochloride NS-018 hydrochloride Tyrosine Kinases , JAK
Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.
T22338 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide GDC046 Others , JAK
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
T22142 RO8191 RO4948191,CDM-3008 HCV Protease , HBV , JAK , IFNAR , STAT
RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
T5049 NVP-BSK805 NVP-BSK805 2HCl,BSK 805 Tyrosine Kinases , JAK
NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.
T11706 Londamocitinib AZD4604 JAK
Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.
T1849 Momelotinib CYT11387,CYT387,LM-1149 Apoptosis , JAK , Autophagy
Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhib...
T35899 JAK1-IN-8 JAK1-IN-8 JAK
JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
T3998 Itacitinib INCB39110,INCB039110 JAK
Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.
T1929 Filgotinib GLPG0634 Tyrosine Kinases , JAK
Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.
T3043 Ruxolitinib phosphate INC424,INCB018424,INC 424 phosphate,Ruxolitinib (INCB-18424) phosphate,INCB018424 phosphate Mitophagy , JAK , Autophagy
Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.
T10431 Golidocitinib AZD4205 JAK
Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).
T3080 Pyridone 6 Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I Tyrosine Kinases , JAK
Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM...
TQ0037 Abrocitinib PF-04965842 JAK
Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).
T3076 GLPG0634 analog GLPG0634 analogue Tyrosine Kinases , JAK
GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.

Compounds

JAK1/2/3 Inhibitor 1
T77504
Synonym:
Target: PKA
Povorcitinib phosphate
T39113L
Synonym:
Target: JAK
SHR0302
T9195
Synonym: ARQ252
Target: Apoptosis, JAK
Ilginatinib
T12266
Synonym: NS-018
Target: Tyrosine Kinases, JAK
Upadacitinib
T7503
Synonym: ABT-494
Target: JAK
Ilginatinib maleate
T12266L
Synonym: NS-018 maleate
Target: Tyrosine Kinases, JAK
Ilginatinib hydrochloride
T12266L2
Synonym: NS-018 hydrochloride
Target: Tyrosine Kinases, JAK
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
T22338
Synonym: GDC046
Target: Others, JAK
RO8191
T22142
Synonym: RO4948191,CDM-3008
Target: HCV Protease, HBV, JAK, IFNAR, STAT
NVP-BSK805
T5049
Synonym: NVP-BSK805 2HCl,BSK 805
Target: Tyrosine Kinases, JAK
Londamocitinib
T11706
Synonym: AZD4604
Target: JAK
Momelotinib
T1849
Synonym: CYT11387,CYT387,LM-1149
Target: Apoptosis, JAK, Autophagy
JAK1-IN-8
T35899
Synonym: JAK1-IN-8
Target: JAK
Itacitinib
T3998
Synonym: INCB39110,INCB039110
Target: JAK
Filgotinib
T1929
Synonym: GLPG0634
Target: Tyrosine Kinases, JAK
Ruxolitinib phosphate
T3043
Synonym: INC424,INCB018424,INC 424 phosphate,Ruxolitinib (INCB-18424) phosphate,INCB018424 phosphate
Target: Mitophagy, JAK, Autophagy
Golidocitinib
T10431
Synonym: AZD4205
Target: JAK
Pyridone 6
T3080
Synonym: Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I
Target: Tyrosine Kinases, JAK
Abrocitinib
TQ0037
Synonym: PF-04965842
Target: JAK
GLPG0634 analog
T3076
Synonym: GLPG0634 analogue
Target: Tyrosine Kinases, JAK
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